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Mass-defect tagging for proteomic analysis
Genetic Engineering News, Volume 24, Number 8, April 15, 2004
Abstract
Luke V. Schneider, Ph.D., Michael P. Hall, Ph.D., and Michael M. Brasseur
Mass spectrometry has the ability to analyze DNA, peptides, proteins, and small molecule drugs in automated, high-throughput assays, enabling and/or improving such applications as protein target identification, validation, ADMET assays, and others. The unique advantage of MS-based assays is the ability to gain more molecular-level information about an analyte, such as posttranslational modifications, and thus add more clinical relevance to the assay.
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